Indian Study of Women with Cervical Lesions called Unethical

Abstract

Doctors in India are questioning the ethics of a study which observed the natural course of precancerous uterine cervical lesions without treatment in women who had not given written consent to take part. In at least nine women the lesions progressed to invasive cancer, and 62 women developed carcinoma in situ of the cervix before they were treated.

In an attempt to study rates of progression of uterine cervical dysplasias to malignancy, the Indian Council of Medical Research during 1976-88 allocated 1158 women with varying degrees of cervical dysplasias to long term follow up. The development of carcinoma in situ was defined as the end point for treatment.